Garlic's allicin aids heart recoveryMetagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
Moderate relevance to heart attack
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
Read More
Garlic compounds improve heart healthCardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
Study blends garlic with medications
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
Read More