Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
Read More
9
Garlic compounds improve heart health
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
Read More
Most Useful Reviews
9
Prevention evidence
8 people found this helpful
Dr Matthew Budoff’s study showed that Kyolic garlic extract can prevent heart attack by reducing arterial plaque accumulation. Patients taking the extract showed a decrease in plaque, while the placebo group saw an increase. He recommends 1200 mg daily for heart health, highlighting its effectiveness in lowering homocysteine levels, a heart disease marker.
Read More
7.5
Cholesterol improvement
2 people found this helpful
This supplement has been a great improvement for my heart health. After using it for years, I observed better cholesterol numbers as well as reduced blood pressure.
Read More
9
Healthy heart benefits
1 people found this helpful
This product genuinely works! It helps maintain a healthy gut and immune system while promoting good cholesterol levels, all of which benefit my heart health. Highly recommended.
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
Read More
8
Garlic's allicin aids heart recovery
Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
Prevention evidence
8 people found this helpful
Dr Matthew Budoff’s study showed that Kyolic garlic extract can prevent heart attack by reducing arterial plaque accumulation. Patients taking the extract showed a decrease in plaque, while the placebo group saw an increase. He recommends 1200 mg daily for heart health, highlighting its effectiveness in lowering homocysteine levels, a heart disease marker.
Read More
7.5
Cholesterol improvement
2 people found this helpful
This supplement has been a great improvement for my heart health. After using it for years, I observed better cholesterol numbers as well as reduced blood pressure.
Read More
9
Healthy heart benefits
1 people found this helpful
This product genuinely works! It helps maintain a healthy gut and immune system while promoting good cholesterol levels, all of which benefit my heart health. Highly recommended.
Read More
7.5
Regular heart supplement
1 people found this helpful
This is a regular supplement I take for my heart health, and I will definitely purchase it again.
Read More
7.5
Improved heart health
30 people found this helpful
Kyolic Aged Garlic has had a beneficial impact on my mother's heart health. In 2002, doctors said she was 99% blocked and placed her on hospice care. I began giving her this supplement alongside others, and remarkably, she is still with us and better today than 21 years ago. I believe Kyolic has slowed the progression of atherosclerosis and will continue to provide it.
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Garlic, scientifically known as Allium sativum, is a popular culinary ingredient that is renowned for its distinctive flavor and numerous health benefits. Belonging to the onion family, it is closely related to leeks and shallots. Garlic is typically used in various cuisines worldwide, lending its pungent, savory notes to a range of dishes from pasta sauces to roasted meats. Whether consumed raw, sautéed, or roasted, garlic not only enhances the taste of food but is also prized for its potential health properties, including its antimicrobial effects and ability to boost the immune system.
In addition to its culinary uses, garlic is often celebrated in alternative medicine for its health benefits. It is rich in essential nutrients, including vitamins C and B6, manganese, and selenium. Furthermore, research suggests that garlic may help lower blood pressure, improve cholesterol levels, and provide antioxidant effects. When buying garlic, opt for firm, dry bulbs with tight skin and avoid any signs of sprouting or softness. Fresh garlic cloves can easily elevate your cooking game, making them a staple in kitchens around the globe.
Garlic has long been celebrated for its potential health benefits, especially when it comes to heart health. Various studies suggest that garlic may help to lower blood pressure and improve cholesterol levels, both of which are significant risk factors for heart disease and heart attacks. The active compounds in garlic, such as allicin, are believed to contribute to these cardiovascular benefits by helping to relax blood vessels and reduce inflammation. While garlic can be a healthy addition to your diet, it's essential to view it as part of a comprehensive approach to heart health, which includes a balanced diet, regular physical activity, and other lifestyle changes.
However, it's important to note that while garlic may support heart health, it should not be relied upon as a sole treatment or prevention strategy for heart attacks. Always consult with a healthcare professional for personalized advice, especially if you have existing health conditions or are on medication. While the incorporation of garlic can be a flavorful and healthful addition to your meals, it should be part of a well-rounded diet and not a substitute for proven medical treatments.
Based on user reviews of the supplement, the timeline for seeing results can vary significantly. Many users report improvements in their heart health within several months of consistent use. For instance, a user mentioned that after a year of taking the supplement, they experienced noticeable improvements in heart health Read Review. Another user confirmed a similar duration, stating they effectively lowered their blood pressure after a year of regular intake Read Review.
On the other hand, some users noted that they began to see changes in their cholesterol levels and blood pressure within a few months Read Review. Overall, while individual experiences may vary, most users suggest a continued commitment to the supplement for ideally three to twelve months to truly gauge its effectiveness in supporting heart health.
Garlic and its active compounds have garnered interest in the context of heart health, particularly regarding heart attack recovery and prevention. Research indicates that allicin, a key component of garlic, may play a role in supporting heart recovery after myocardial infarction. In a study involving mice that experienced acute myocardial infarction, allicin treatment significantly reduced myocardial injury and inflammation while improving overall heart function over a 28-day period [1]. These findings suggest allicin might be a beneficial supplementary treatment alongside conventional therapies for heart attacks, indicating its potential in enhancing recovery outcomes.
Further supporting the heart-protective properties of garlic, another study involving rats with induced heart damage demonstrated that garlic oil and its active compound, diallyl disulfide, could improve heart health when used in conjunction with the heart medication carvedilol. This combination reduced harmful cardiac enzymes and markers of inflammation, while increasing antioxidant enzyme activity [2]. Thus, incorporating garlic and its compounds, particularly when combined with established heart medications, shows promise in contributing to cardioprotection and overall heart health.
Users have reported a range of improvements in their heart health after taking the supplement, highlighting its effectiveness in managing various cardiovascular symptoms. For example, one user noted significant improvements in both cholesterol levels and blood pressure after years of consistent use Read Review. Another user shared an inspirational story about their mother, who, despite being told she was 99% blocked and placed in hospice care, has shown remarkable recovery and is healthier 21 years later with the help of the supplement, which they believe has slowed atherosclerosis progression Read Review.
Additionally, many users emphasize the immediate benefits of improved gut health, lower blood pressure, and reduced symptoms like chest pain after starting the supplement Read ReviewRead Review. While individual experiences vary, the consensus among users is that consistent usage over several months leads to noticeable benefits, reinforcing the supplement’s role in supporting heart health Read Review.
Users have reported a mix of experiences when combining this supplement with other products for enhancing heart health. One user shared a compelling account of their mother, who, despite being told she was critically ill, thrived for over 21 years after starting Kyolic Aged Garlic alongside other supplements Read Review. This suggests that combining supplements can yield significant health benefits, particularly in managing severe cardiovascular conditions. Furthermore, one reviewer noted that their spouse has successfully relied on this supplement as a substitute for blood pressure medications after receiving professional recommendations, indicating a synergistic effect when paired with a comprehensive health regimen Read Review.
While many users emphasize the benefits of using the supplement alongside their regular health routine, the results can vary. For example, another user mentioned that their experience differed from others who reported substantial blood pressure reductions, indicating that individual responses to supplements can differ widely Read Review. Overall, user reviews suggest that while combining this supplement with others may enhance heart health for some, outcomes can be inconsistent among different individuals.
Based on user reviews, the recommended dosage of Kyolic garlic extract for optimal heart health treatment appears to be around 1200 mg daily. This recommendation stems from Dr. Matthew Budoff's study, which highlighted the extract's effectiveness in reducing arterial plaque and improving heart-related metrics, including lowering homocysteine levels, a known marker for heart disease Read Review. Users have reported positive changes in their heart health and cholesterol levels after consistent use, with many citing improvements over long periods of taking the supplement.
Additionally, customers have shared experiences indicating that the garlic extract plays a significant role in maintaining low blood pressure and promoting overall cardiovascular health Read Review. Some users have noted that upon stopping the supplement, they observed a rise in blood pressure, which improved again upon resuming, underlining the efficacy of consistent dosing in managing heart health Read Review. Although some individuals reported mixed results, the consensus among users is that a daily intake of 1200 mg is beneficial for heart health, particularly when taken consistently.
7.5
Heart health improved
2 people found this helpful
I have been using this supplement for the past year, and my heart health has noticeably improved during this time.
7.5
Lowered blood pressure
4 people found this helpful
I’ve taken these capsules for about a year, and they have effectively helped lower my blood pressure. I conducted a self-experiment by stopping the capsules, leading to increased blood pressure numbers. After resuming, my numbers improved again. There’s no aftertaste, and I appreciate that this brand is non-GMO and free from sugar and artificial ingredients.
7.5
Cholesterol improvement
2 people found this helpful
This supplement has been a great improvement for my heart health. After using it for years, I observed better cholesterol numbers as well as reduced blood pressure.
7.5
Improved heart health
30 people found this helpful
Kyolic Aged Garlic has had a beneficial impact on my mother's heart health. In 2002, doctors said she was 99% blocked and placed her on hospice care. I began giving her this supplement alongside others, and remarkably, she is still with us and better today than 21 years ago. I believe Kyolic has slowed the progression of atherosclerosis and will continue to provide it.
9
Healthy heart benefits
1 people found this helpful
This product genuinely works! It helps maintain a healthy gut and immune system while promoting good cholesterol levels, all of which benefit my heart health. Highly recommended.
7.5
Chest pain relief
1 people found this helpful
This product is excellent for heart health. I used to suffer from chest pain, which has gradually decreased since I started taking it. I advise consulting a doctor if chest pain persists.
9
Stable blood pressure
7 people found this helpful
Kyolic Aged Garlic Extract is an excellent product. It’s extra strength with no garlic breath and helps maintain low blood pressure. My husband has relied on it for years for his heart health after a practitioner advised its benefits. He avoids blood pressure medications thanks to this fantastic product. Many thanks for producing this outstanding supplement.
2
Ineffective treatment
Quite acceptable. Many take it for heart health, and I do too, but it doesn't lower blood pressure as others claim. Perhaps it works for some, but not for me.
9
Prevention evidence
8 people found this helpful
Dr Matthew Budoff’s study showed that Kyolic garlic extract can prevent heart attack by reducing arterial plaque accumulation. Patients taking the extract showed a decrease in plaque, while the placebo group saw an increase. He recommends 1200 mg daily for heart health, highlighting its effectiveness in lowering homocysteine levels, a heart disease marker.
8
Garlic's allicin aids heart recovery
Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
9
Garlic compounds improve heart health
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
References
Gao Y, Qin G, Liang S, Yin J, Wang B, et al. Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin. Drug Des Devel Ther. 2025;19:771. 10.2147/DDDT.S504884
Asdaq SMB, Alamri AS, Alsanie WF, Alhomrani M. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules. 2021;26. 10.3390/molecules26175137